Adeno-Associated Virus Production Service

Adeno-associated virus (AAV) is a small (20 nm in diameters) replication-defective and nonenveloped virus that infects humans and some other primate species. AAV is not presently known to result in disease and consequently the virus causes a very mild immune response. Recombinant AAV vectors can efficiently transfect multiple cell types, including quiescent and dividing cells, and induce persistent gene expression in vivo without integrating into host genome and causing any disease. These features make AAV a useful tool for gene delivery into a variety of cell types and an attractive vector for gene therapy. So far, more than 200 clinical trials have been carried out using AAV vectors for gene delivery, and promising gene therapy outcomes have been achieved from clinical trials for a number of diseases.

Creative Biogene has developed a QVirus™ platform that suits all your needs when it comes to combining scientific development and processing advancements in the field of gene therapy. With QVirus™ Platform’s robust AAV production system, using AAV as a therapeutic vehicle for a broad range of diseases is now a simple task. We can provide the most robust and professional AAV packaging service, ranging from small crude scale to the custom large purified scale.

  • Selecting AAV serotypes

We offer AAV cloning and packaging in multiple serotypes (AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV-DJ/8 and AAV-DJ).

Tissue Tropism (* indicates recommended application)

AAV SerotypeMuscleHeartLungLiverCNS/RetinaKidneyPancreas
AAV1*** * *
AAV2   *** 
AAV3 * **  
AAV4 *  *  
AAV5  * *  
AAV6***    
AAV7*   *  
AAV8*  ** *
AAV9*******
AAV-DJA mix of 8 naturally occurring serotyes. Efficient for multiple types of human tissues and organs.
  • Wide choice of AAV cis vectors

Promoter: CMV, PGK, U6, UBC, EF1α, ELA1, TRE-miniCMV, MHCK7, ApoE/AAT1, CaMKII, cTNT, GFAP, MBP, SST, TBG, αMHC, hRPE, tMCK, etc.
Reporter: GFP, mCherry, strawberry, LacZ, Luc, mRFP, eYFP, Venus, TRE-miniCMV, CMVtight, MHCK7, etc.

  • From small crude scale to large purified scale

Small scale: >5x1012GC/ml, 500µl
Large scale: >1x1013GC/ml, 500µl

  • Multiple AAV purification

(1) Lodixanol gradient purification
(2) Affinity and ion exchange chromatography

  • AAV titration

We provide AAV titration (measuring genome copies) by qPCR. Furthermore, endotoxin measurement and reduction, SDS PAGE, and TCID50 assay are also available.

QVirus™ Platform's benefits include:

  • Personal expert consultation at all stages of the project
  • Strong tissue targeting with a unique serotype and promoter portfolio
  • Highest quality standards and purification options to satisfy your experimental needs
  • AAV delivery in less than two months

QVirus™ Platform provides engineered AAV vectors for gene expression and knockdown experiments, which help uncover the phenotypic impact of genetic modification on the level of the living organism. If you have any special requirements, please feel free to contact us.

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